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Pregled bibliografske jedinice broj: 860345

Eco-friendly rapid synthesis of 3-substituted- 2- thioxo-2, 3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent


Molnar, Maja; Klenkar, Jelena; Tarnai, Tena
Eco-friendly rapid synthesis of 3-substituted- 2- thioxo-2, 3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent // Synthetic communications, 47 (2017) 1040-1045. doi:10.1080/00397911.2017.1291815 (članak, znanstveni)


Naslov
Eco-friendly rapid synthesis of 3-substituted- 2- thioxo-2, 3-dihydroquinazolin-4(1H)-ones in choline chloride based deep eutectic solvent

Autori
Molnar, Maja ; Klenkar, Jelena ; Tarnai, Tena

Izvornik
Synthetic communications (0039-7911) 47 (2017), ; 1040-1045

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Deep eutectic solvents ; 2-thioxo-2, 3-dihydroquinazolin-4(1H)-ones ; anthranilic acid ; 5-iodoanthranilic acid ; isothiocyanate

Sažetak
A series of 3-substituted-2-thioxo-2, 3- dihydroquinazolin-4(1H)-ones and 6-iodo-3- substituted-2-thioxo-2, 3-dihydroquinazolin- 4(1H)-ones were synthesized in choline chloride/urea deep eutectic solvent. Substituted 2-mercapto-4(3H)-quinazolinones were synthesized from anthranilic acid or 5- iodoanthranilic acid and appropriate isothiocyanates in good to excellent yields. Isolation of final product was easy and required no further purification. Synthesis of these compounds was rapid, selective and catalyst free, while preparation of deep eutectic solvent was easy, components are readily available, cheap and environmentally friendly.

Izvorni jezik
Engleski

Indeksirano u
Current Contents , Web of Science Core Collection

Znanstvena područja
Kemija

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